Erythropoiesis stimulantsはがん患者でVTE、死亡のリスクを上げる
化学療法で貧血あるがん患者にエリスロポエチン投与すると、
死亡率↑、VTE↑
meta-analysis
mortality : 51 clinical trial, n=13,611
VTE : 38 clinical trial, n= 8,172
結果
・death HR 1.1
・VTE 7.5% vs 4.9%, RR 1.57
thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia.
JAMA. 2008 Feb 27; 299(8):914-924.
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