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ビスホスホネートは5年以上投与すべきではない?

逆説的な薬:長期投与で骨折を招くビスフォスフォネート


「海外ではビスフォスフォネート製剤が骨吸収を強く抑制するため,理論的にはmicrodamageの蓄積により長期投与ではfrozen bone(adynamic bone disease)をきたし,かえって骨折のリスクを増やすのではないかという懸念が開発当初からあり,ビスフォスフォネート製剤の至適投与期間を知るべく,いくつかの臨床試験が行われている.」

とのこと。とても興味深い。

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