強化インスリン療法の効果は、よくわからない
●ACCORD study, NEJM 2008;358:2545-2559
HbA1c 目標7.0〜7.9 と 目標6.0未満を比べたら、後者の方が死亡率が高かった →試験を途中で中止
●ADVANCE study, NEJM 2008;358:2560-2572
標準 vs 6.5以下
→腎症の発生率が低下していた(HR 0.79)
主要大血管・全死亡率 には明らかな差異はなかった
http://content.nejm.org/cgi/content/full/NEJMoa0802743
日本語の情報
http://rockymuku.sakura.ne.jp/naibunnpitunaika/ACCORD.pdf
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